ABSTRACT
Plasma lipids of 24 euthyroid subjects with thyroid adenoma and non-toxic primary differentiated thyroid carcinoma (papillary and follicular types) were assessed and compared with a similar investigation conducted on 20 normal subjects. A parallel study with thyroid tumor tissues examined the lipid changes which occurred in the same group of patients. These were compared with the picture seen in 5 normal thyroids. The investigations examined the changes in total lipids; total, free and esterified cholesterol; total phospholipids; lecithin; cephalin and sphingomyelin; triglycerides and free fatty acids in both serum and thyroid tissue. Compared with normal subjects, the serum lipids were almost identical except for the concentration of free fatty acids which showed significantly lower values in the group with neoplastic changes. Tissue analysis of the cancerous thyroid however revealed a marked rise in virtually all lipid fractions but the cholesterol seemed to dominate the picture. The differential studies of total phospholipids for thyroid tissue membrane lipids further revealed a significant increase in the lecithin and sphingomyelin components of total phospholipids as well as the esterified cholesterol fraction in thyroid carcinoma. The changes in thyrophospholipids were more marked in females normal thyroids than males. An attempt has been made through evaluation of the results derived from differential lipid studies to elucidate the role of some of the various fractions determined and the possible effect of the changes described on thyroid hormone metabolism.
Subject(s)
Adenocarcinoma/analysis , Adenoma/analysis , Cholesterol/analysis , Fatty Acids/analysis , Female , Humans , Lipids/analysis , Male , Phospholipids/analysis , Thyroid Gland/analysis , Thyroid Neoplasms/analysis , Triglycerides/analysisABSTRACT
Se analizan 22 casos de cáncer de tiroides, tratados en el Hospital Regional de Talca, entre 1974 y 1986. Hubo 19 mujeres y 3 hombres, entre 23 y 90 años de edad. La procedencia geográfica se repartió por igual entre la región urbana y rural. En mujeres esta enfermedad se asoció a grandes multíparas en 52%; a hipertensión arterial en 47% y en ambas patologías en 31% de los casos. Hubo 86% de bocios uninodulares y 14% multinodulares. La indicación quirúrgica fue por sospecha de neoplasia maligna. Hubo 81% de carcinomas diferenciados. De éstos, 55% son foliculares y 45% papilares. Carcinomas indiferenciados en 19% de los casos. El procedimiento quirúrgico más frecuente utilizado fue la tiroidectomía total. Entre las complicaciones de cirugía, el hipoparatiroidismo definitivo se presentó en dos casos. No hubo mortalidad operatoria. El seguimiento y control de los pacientes se realizó en todos los casos por un período de 13 años, observándose que todos los cánceres diferenciados están vivos y sanos (18 casos); con sobrevida con más de 5 años hay 12 casos y con 10 años, existen 5 casos. Todos los carcinomas indiferenciados están fallecidos
Subject(s)
Adult , Middle Aged , Humans , Male , Female , Thyroid Neoplasms/epidemiology , Thyroidectomy , Thyroid Neoplasms/analysis , Chile , RiskABSTRACT
Uma amostra de carcinoma medular de tireóide foi cultivada por 29 dias, tendo-se dosado a CT secretada para o meio de cultura a cada 24-48 h. Os níveis iniciais de CT (> 1000 pg/ml) demonstraram queda gradativa até o 20§ dia (110 pg/ml). Entre os dias 20 e 29, os níveis de CT secretada para o meio se mantiveram constantes. Esta abordagem abre uma nova oportunidade em nosso meio no estudo deste tumor e na sua confirmaçäo diagnóstica